Effectiveness of Using Vitamin B Complex for Increasing Appetite in NCDs Older Patients with Loss of Appetite at Bangpoon 1 Sub-district Health Promoting Hospital Effectiveness of using Vitamin B Complex for increase appetite in NCDs older patients who loss of appetite at Bangpoon 1 District Health Promotion Hospital

Main Article Content

Thanyawan Petchnoi

Abstract

Background: Loss of appetite in older adults is a reduction of food desire or low food intake. Oftens not detected or corrected. A decreased appetite can cause malnutrition, dehydration, weight loss, infection, frailty, sarcopenia, poor quality of life. Objections were to study the effect on appetite, changes in body composition, physical performance, cognition, adverse effects after taking vitamin B complex.


Design: Quasi-experimental study with one group pre-posttest design


Methods: The sample size was 40. Aged ≥ 60 years-old with NCDs at Bangpoon 1 Sub-district Health Promoting Hospital who loss of appetite and had a Thai version of the short nutritional assessment questionnaire score ≤14. The sample was selected by convenience sampling. Data were collected for 4 months from March 1st to June 30th, 2024. Data were analyzed using N, %, Mean ± SD., Median ± IQR, Paired sample T-test and Wilcoxon signed-rank test.


Results: Only 30 participants can remain. Women 96.7%. Average age is 73.30±6.65 years old. The study found the appetite score, hip circumference, hand grip strength, gait speed, cognition score were increased at 3 months statistically significant. Meanwhile, body weight, subcutaneous skinfold thickness, calf circumference were decreased at 3 months, statistically significant.


Conclusions: Vitamin B complex helps increase appetite, hip circumference, handgrip strength, gait speed, and cognition. But it causes weight loss. Skin fold thickness and calf circumference decreased. A serious adverse effect was not found.


Keywords: older adults, loss of appetite, vitamin B complex

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1.
Petchnoi T. Effectiveness of Using Vitamin B Complex for Increasing Appetite in NCDs Older Patients with Loss of Appetite at Bangpoon 1 Sub-district Health Promoting Hospital : Effectiveness of using Vitamin B Complex for increase appetite in NCDs older patients who loss of appetite at Bangpoon 1 District Health Promotion Hospital. PCFM [internet]. 2026 Apr. 30 [cited 2026 May 3];9(2). available from: https://so03.tci-thaijo.org/index.php/PCFM/article/view/282123
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References

ปณิตา ลิมปะวัฒนะ. กลุ่มอาการผู้สูงอายุและประเด็นทางสุขภาพที่น่าสนใจ. พิมพ์ครั้งที่ 2. ขอนแก่น: คลังนานาวิทยา; 2561. 6, 152-62.

Barreto PDS, Cesari M, Morley JE, Roberts S, Landi F, Cederholm T, et al. Appetite loss and anorexia of aging in clinical care: an ICFSR task force report. J Frailty Aging. 2022;11:129-34.

Merchant RA, Woo J, Morley JE. Anorexia of ageing: pathway to frailty and sarcopenia. J Nutr Health Aging. 2022;26:3-5.

Pilgrim A, Robinson S, Sayer AA, Roberts H. An overview of appetite decline in older people. Nurs Older People. 2015;27:29-35.

Das T, Ghosh S. Anorexia in Elderly. Bengal Physician Journal. 2019;6:1-7.

Champion A. Anorexia of aging [Internet]. 2011 [cited 2023 July 25th]. Available from: http://www.hmpgloballearningnetwork.com/site/altc/articles/anorexia-aging

O’Brien K, Lindquist LA. Anorexia of aging. Today’s Geriatric Medicine. 2017;10:14.

Norman K, Haß U, Pirlich M. Malnutrition in older adults-recent advances and remaining challenges. Nutrients. 2021;13:1-20.

Morley JE. Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia. J Cachexia, Sarcopenia and Muscle. 2017;8:523-26.

Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. New horizons in appetite and the anorexia of ageing. Age and Ageing. 2020;49:526-34.

Morley JE, Silver AJ. Anorexia of aging. Neurobiology of Aging. 1988;9:9-16.

Amarya S, Singh K, Sabharwal M. Changes during aging and their association with malnutrition. Journal of Clinical Gerontology & Geriatrics. 2015;6:78-84.

Francesco VD, Pellizzari L, Corra L, Fontana G. The anorexia of aging: impact on health and quality of life. Geriatric care. 2018; 4(7324). doi: 10.4081/gc.2018.7324

สถาบันเวชศาสตร์สมเด็จพระสังฆราชญาณสังวรเพื่อผู้สูงอายุ กรมการแพทย์ กระทรวงสาธารณสุข. คู่มือแนวทางการดำเนินงานคลินิกผู้สูงอายุคุณภาพและประเด็นสำคัญด้านเวชศาสตร์ผู้สูงอายุในแผนกผู้ป่วยนอก. นนทบุรี: ซีจีทูล; 2562. หน้า 36.

Nagaraj S. Loss of appetite in adult patients: Effectiveness and safety of an appetite stimulating medication in an open-label, Investigator-initiated study in India. Hindawi journal of nutrition and metabolism 2022. doi: 10.1155/2022/2661912

Wilson MGG, Thomas DR, Rubenstein LZ, Chibnall JT, Anderson S, Baxi A, et al. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutri. 2005;82;1074-81.

Mims. Vitamin B complex GPO [Internet]. n.d. [cited 2023 September 21st]. Available from: http://www.mims.com/thailand/drug/info/vitamin%20b%20complex%20gpo

กลุ่มงานเภสัชกรรมและคุ้มครองผู้บริโภค โรงพยาบาลป่าพะยอม จังหวัดพัทลุง. Vitamin B complex tablet [อินเตอร์เน็ต]. ม.ป.ป.[เข้าถึงเมื่อ 2566 กันยายน 21]. เข้าถึงได้จาก: http://www.paphayomhospital.go.th/medicine/file/Vitamin%20B%20complex%20Tablet.pdf

Othman M, Kanjo M, Tasji T, Rushan M, Tasji AK, Tasji WK, et al. Understanding the Impact of Vitamin B Supplements on a Saudi Population. Cureus. 15(12): e50626. PubMed PMID: 38226090

Dhir S, Tarasenko M, Napoli E, Giulivi C. Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults. Front Psychiatry. 2019;10;207. PubMed PMID: 31019473

คณะกรรมการและคณะทำงานปรับปรุงข้อกำหนดสารอาหารที่ควรได้รับประจำวันสำหรับคนไทย. ปริมาณสารอาหารอ้างอิงที่ควรได้รับประจำวันสำหรับคนไทย พ.ศ. 2563 (Dietary Reference Intake For Thais 2020). กรุงเทพ : สำนักโภชนาการ กรมอนามัย กระทรวงสาธารณสุข; 2563. หน้า 182.

Liu M, Alimov AP, Wang H, Frank JA, Katz W, Xu M. et al. Thiamine Deficiency Induces Anorexia By Inhibiting Hypothalamic AMPK. Neuroscience 2014; 267:102-13.

Wysokiski A, Sobów T, Kłoszewska I, Kostka T. Mechanisms of the anorexia of aging-a review. Age (Dordr). 2015;37(4):9821. PubMed PMID: 26232135

Landi F, Calvani R, Tosato M, Martone AM, Ortolani E, Savera G, et al. Anorexia of aging: risk factors, consequences, and potential treatments. Nutrients 2016;8(2):69. PubMed PMID: 26828516

Ohta R, Ryu Y, Hattori S. Association between transient appetite loss and vitamin B1 deficiency in elderly patients with suspected deficiency. J Gen Fam Med. 2021;22:128-33.

Kirkland JB, Ficca MLM. Niacin. Advances in Food and Nutrition Research. 2018;83:83-132.

Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, et al. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol. 2010;16:2378-87.

Porter K, Hoey L, Hughes CF, Ward M, McNulty H. Causes, consequences and public health implications of low b-vitamin status in ageing. Nutrients. 2016;8(11):725: PubMed PMID: 27854316

Liu L, Wang H, Sun H, Fu C, Liu H, Sun Y, et al. Effects of Pyridoxine on Selected Appetite Regulating Peptides mRNA Expression in Hypothalamic PVN/ARC Nuclei and Gastrointestinal Tract Tissues. Advances in Bioscience and Biotechnology. 2017;8:273-82.

Zheng Y, Ma AG, Zheng MC, Wang GZ, Liang H, Han XX. B vitamins can reduce body weight gain by increasing metabolism-related enzyme activities in rats fed on a high-fat diet. Curr Med Sci. 2018;38: 174-83.

Fu Y, Zhu Z, Huang Z, He R, Zhang Y, Li Y, et al. Association between vitamin B and obesity in middle-aged and older Chinese adults. Nutrients 2023;15(3):438. PubMed PMID: 36771189

Agraib LM, Shami IA, Alkhatib B, Hasan H. The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study. F1000 Research. 2024;12:1382. PubMed PMID: 39140087

Maguire D, Talwar D, Shiels PG, McMillan D. The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review. Clin Nutr ESPEN. 2018;25:8-17.

Tanaka T, Kono T, Terasaki F, Yasui K, Soyama A, Ostuka K. The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review. Journal of Nutritional Science and Vitaminology. 2010;56:335-46.

Zemel MB, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects. Diabetes Metab Syndr Obes. 2013;6:309-15.

Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F. The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women. Clin Nutr Res. 2021;10:230-42.

Marshall WJ, Lapsley M, Day AP, Ayling RM, editors. Clinical biochemistry Metabolic and clinical aspect. 3rd ed. China: Elsevier; 2014. p. 194.

Godoy-Parejo C, Deng C, Zhang Y, Liu W, Chen G. Roles of vitamins in stem cells. Cellular and Molecular Life Sciences. 2020;77:1771-91.

Kumar A. Correlation between anthropometric measurement, lipid profile, dietary vitamins, serum antioxidants, lipoprotein (a) and lipid peroxides in known cases of 345 elderly hypertensive South Asian aged 56-64 y-A hospital-based study. Asian Pac J Trop Biomed. 2014;4:S189-97.

Yang S, Dong Z, Zhao J, Yuan L, Xiao Y, Luo X, et al. Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018. Front Nutr. 2024;11:1369331. PubMed PMID: 38549750

Aytekin N, Mileva KN, Unliffe AD. Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations. Nutr Res Rev. 2018;31:204-24.

Kwon K, Jang HJ, Yu SN, Cheol AS, Yu KO. Elderly Sarcopenia and Vitamin B Deficiency: A Relationship? Journal of Life Science. 2023;33:574-85.

Robinson S, Granic A, Sayer AA. Micronutrients and sarcopenia: current perspectives. Proc Nutr Soc. 2021;80:311-8.

Jentoft AJC, Sayer AA. Sarcopenia. Lancet. 2019; 393(10191):2636-46.

Xiang S, Li Y, Li Y, Zhang J, Pan W, Lu Y, Liu S. Increased dietary niacin intake improves muscle strength, quality, and glucose homeostasis in adults over 40 years of age. J Nutr Health Aging. 2023;27:709-18.

Grootswagers P, Mensink M, Berendsen AAM, Deen CPJ, Kema IP, Bakker SJL. Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study. Am J Clin Nutr. 2021;113:781-89.

Wang Z, Zhu W, Xing Y, Jia J, Tang Y. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis. Nutr Rev. 2022;80:931-49.

Li S, Guo Y, Men J, Fu H, Xu T. The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis. BMC Geriatr. 2021;21(367). PubMed PMID: 34134667

Cheng D, Kong H, Pang W, Yang H, Lu H, Huang C, et al. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016;19:461-66.

Jager CAD, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012;27:592-600.