Spatial Epidemiology of Infectious Diseases in Indonesia: Patterns, Clusters, and Environmental Determinants
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Abstract
Indonesia’s vast geography, high population density, and environmental diversity contribute to uneven patterns of infectious disease transmission. This study aims to explore the spatial distribution and environmental influences of seven key infectious diseases—acute respiratory infections (ARI), pneumonia, tuberculosis (TB), hepatitis, diarrhea, malaria, and filariasis—across the country's 34 provinces. We used data from the 2018 National Health Survey and the 2018 Environmental Quality Index (EQI). Spatial statistical techniques—including the Variance Mean Ratio (VMR), Moran’s I, Moran Scatter Plots, and Spatial Autoregressive (SAR) modeling—were applied to detect spatial clustering, spatial autocorrelation, and neighborhood effects. We also examined the role of environmental quality in shaping disease patterns. Most infectious diseases demonstrated significant spatial clustering, with Java Island and its surrounding areas showing the highest concentration. Strong spatial correlations were observed among ARI, pneumonia, TB, hepatitis, diarrhea, and filariasis. In contrast, malaria displayed a distinct, uncorrelated pattern. SAR modeling revealed positive spatial spillover effects, indicating that neighboring provinces influenced disease occurrences in the province under study. Moreover, provinces with higher EQI scores tended to have lower rates of ARI, TB, diarrhea, and other diseases—except for malaria, which followed a different pattern. The findings suggest that infectious disease patterns in Indonesia are not random but geographically clustered and environmentally influenced. Targeted health interventions that consider both spatial dynamics and environmental quality are essential for effective disease control and prevention.
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References
• Amsalu, E. T., Akalu, T. Y., & Gelaye, K. A. (2019). Spatial distribution and determinants of acute respiratory infection among under-five children in Ethiopia: Ethiopian Demographic Health Survey 2016. PLOS ONE, 14(4), Article e0215572. https://doi.org/10.1371/journal.pone.0215572
• Anselin, L. (2024). An introduction to spatial data science with GeoDa: Volume 1: Exploring spatial data. CRC Press.
• Batura, N., Kasteng, F., Condoane, J., Bagorogosa, B., Castel-Branco, A. C., Kertho, E., Källander, K., Soremekun, S., Lingam, R., & Vassall, A., for the inSCALE Study Group. (2022). Costs of treating childhood malaria, diarrhoea, and pneumonia in rural Mozambique and Uganda. Malaria Journal, 21, Article 239. https://doi.org/10.1186/s12936-022-04254-y
• Björkman, A., Cook, J., Sturrock, H., Msellem, M., Ali, A., Xu, W., Molteni, F., Gosling, R., Drakeley, C., & Mårtensson, A. (2017). Spatial distribution of falciparum malaria infections in Zanzibar: Implications for focal drug administration strategies targeting asymptomatic parasite carriers. Clinical Infectious Diseases, 64(9), 1236–1243. https://doi.org/10.1093/cid/cix136
• BPS – Statistics Indonesia. (2018, October 19). Proyeksi penduduk Indonesia 2015–2045: Hasil SUPAS 2015 [Indonesia population projection 2015–2045: Results of SUPAS 2015]. https://www.bps.go.id/id/publication/2018/10/19/78d24d9020026ad95c6b5965/proyeksi-penduduk-indonesia-2015-2045-hasil-supas-2015.html
• BPS – Statistics Indonesia. (2022). Jumlah penduduk pertengahan tahun (ribu jiwa), 2020–2022 [Mid-year population (thousand people), 2020–2022]. https://www.bps.go.id/indicator/12/1975/1/jumlah-penduduk-pertengahan-tahun.html
• Chen, Y. (2024). Reconstruction and normalization of LISA for spatial analysis. PLOS ONE, 19(5), Article e0303456. https://doi.org/10.1371/journal.pone.0303456
• Chirenda, J., Gwitira, I., Warren, R. M., Sampson, S. L., Murwira, A., Masimirembwa, C., Mateveke, K. M., Duri, C., Chonzi, P., Rusakaniko, S., & Streicher, E. M. (2020). Spatial distribution of Mycobacterium tuberculosis in metropolitan Harare, Zimbabwe. PLOS ONE, 15(4), Article e0231637. https://doi.org/10.1371/journal.pone.0231637
• D’Angelo, N., & Adelfio, G. (2025). stopp: An R package for spatio-temporal point pattern analysis. Journal of Statistical Software, 113(10), 1–35. https://doi.org/10.18637/jss.v113.i10
• Daniel, O. (2017). Spatial distribution of tuberculosis in Nigeria and its socioeconomic correlates (Doctoral thesis). Lancaster University. https://eprints.lancs.ac.uk/id/eprint/85146/1/2016DanielPhD.pdf.pdf
• de Souza, D. K., & Bockarie, M. J. (2025). Current perspectives in the epidemiology and control of lymphatic filariasis. Clinical Microbiology Reviews, 37(2), Article e00126-23. https://doi.org/10.1128/cmr.00126-23
• Dmello, M. K., Badiger, S., Kumar, S., Kumar, N., & Dsousa, N. (2022). Spatial and space-time clustering of diarrhoeal cases among under-five children in Karkala, Karnataka: A geospatial analysis. Journal of Clinical and Diagnostic Research, 16(4), LC01–LC05. https://doi.org/10.7860/JCDR/2022/55604.16186
• Ebi, K. L., Vanos, J., Baldwin, J. W., Bell, J. E., Hondula, D. M., Errett, N. A., Hayes, K., Reid, C. E., Saha, S., Spector, J., & Berry, P. (2021). Extreme weather and climate change: Population health and health system implications. Annual Review of Public Health, 42, 293–315. https://doi.org/10.1146/annurev-publhealth-012420-105026
• Gething, P. W., Patil, A. P., Smith, D. L., Guerra, C. A., Elyazar, I. R. F., Johnston, G. L., Tatem, A. J., & Hay, S. I. (2011). A new world malaria map: Plasmodium falciparum endemicity in 2010. Malaria Journal, 10, Article 378. https://doi.org/10.1186/1475-2875-10-378
• Griffith, D. A. (2023). Getis’s spatial filtering legacy: Spatial autocorrelation mixtures in geospatial agricultural datasets. Journal of Spatial Econometrics, 4(1), Article 8. https://doi.org/10.1007/s43071-023-00038-x
• Holt-Lunstad, J. (2022). Social connection as a public health issue: The evidence and a systemic framework for prioritizing the “social” in social determinants of health. Annual Review of Public Health, 43, 193–213. https://doi.org/10.1146/annurev-publhealth-052020-110732
• Kauhl, B., Heil, J., Hoebe, C. J. P. A., Schweikart, J., Krafft, T., & Dukers-Muijrers, N. H. T. M. (2015). The spatial distribution of hepatitis C virus infections and associated determinants. PLOS ONE, 10(9), Article e0135656. https://doi.org/10.1371/journal.pone.0135656
• Kienberger, S., & Hagenlocher, M. (2014). Spatial-explicit modeling of social vulnerability to malaria in East Africa. International Journal of Health Geographics, 13, Article 29. https://doi.org/10.1186/1476-072X-13-29
• Lawson, A. B. (2018). Bayesian disease mapping: Hierarchical modeling in spatial epidemiology (3rd ed.). CRC Press.
• Lönnroth, K., Jaramillo, E., Williams, B. G., Dye, C., & Raviglione, M. (2009). Drivers of tuberculosis epidemics: The role of risk factors and social determinants. Social Science & Medicine, 68(12), 2240–2246. https://doi.org/10.1016/j.socscimed.2009.03.041
• Magna, E. K., Dabi, M., & Tadri, P. (2019). Spatial distribution of malaria in the semi-arid zone of Ghana: A case of the Upper West Region using GIS approach. Journal of Environmental Health and Sustainable Development, 4(1), 670–677. http://jehsd.ssu.ac.ir/article-1-160-en.html
• Messer, L. C., Jagai, J. S., Rappazzo, K. M., & Lobdell, D. T. (2014). Construction of an environmental quality index for public health research. Environmental Health, 13, Article 39. https://doi.org/10.1186/1476-069X-13-39
• Ke, S., Cui, H., & Lu, X. (2025). GeoDetector analysis of spatio-temporal patterns and driving mechanisms of farmland spatial transition within 897 counties in the Yangtze River Economic Belt, China. Humanities and Social Sciences Communications, 12, Article 923. https://doi.org/10.1057/s41599-025-05354-1
• Lewandowsky, S. (2021). Climate change disinformation and how to combat it. Annual Review of Public Health, 42, 1–21. https://doi.org/10.1146/annurev-publhealth-090419-102409
• Liu, Q., Deng, J., Yan, W., Qin, C., Du, M., Wang, Y., Zhang, S., Liu, M., & Liu, J. (2024). Burden and trends of infectious disease mortality attributed to air pollution, unsafe water, sanitation, and hygiene, and non-optimal temperature globally and in different socio-demographic index regions. Global Health Research and Policy, 9, Article 23. https://doi.org/10.1186/s41256-024-00366-x
• Martínez-Zarzoso, I., Badarau, C., Díaz Pavez, L. R., Munguía, J. A. T., & Wacker, K. (2025). Pandemics and environmental performance in a globalized world. Frontiers in Climate, 7, Article 1504804. https://doi.org/10.3389/fclim.2025.1504804
• Ministry of Health of the Republic of Indonesia. (2019). Laporan HNasional Riset Kesehatan Dasar 2018 [Basic Health Research 2018: National Report]. https://layanandata.kemkes.go.id/katalog-data/riskesdas/ketersediaan-data/riskesdas-2018
• Ministry of Health of the Republic of Indonesia. (2023). Statistik dan peta endemisitas malaria di Indonesia [Statistics and maps of malaria endemicity in Indonesia]. https://malaria.kemkes.go.id/
• Ministry of Environment and Forestry of the Republic of Indonesia. (2018). Indeks kualitas lingkungan hidup Indonesia 2018 (IKLH 2018) [Environmental quality index of Indonesia 2018]. https://ppkl.menlhk.go.id/website/filebox/1154/230626140053IKLH%202018.pdf
• Moore, D. S., McCabe, G. P., & Craig, B. A. (2017). Introduction to the practice of statistics (9th ed.). W. H. Freeman and Company.
• Moraga, P. (2024). Spatial statistics for data science: Theory and practice with R. Chapman & Hall/CRC.
• Navidi, W., & Monk, B. (2025). Elementary statistics (4th ed.). McGraw Hill.
• Nutbeam, D., & Lloyd, J. E. (2021). Understanding and responding to health literacy as a social determinant of health. Annual Review of Public Health, 42, 159–173. https://doi.org/10.1146/annurev-publhealth-090419-102529
• Ott, R. L., & Longnecker, M. (2016). An introduction to statistical methods and data analysis (7th ed.). Cengage Learning.
• Pebesma, E., & Bivand, R. (2023). Spatial data science: With applications in R. Chapman & Hall/CRC.
• Permana, D. H., Hasmiwati, Suryandari, D. A., Rozi, I. E., Syahrani, L. L., Setiadi, W., Irawati, N., Rizaldi, Wangsamuda, S., Yusuf, Y., Irdayanti, Aswad, H., Asih, P. B. S., & Syafruddin, D. (2023). The potential for zoonotic malaria transmission in five areas of Indonesia inhabited by non-human primates. Parasites & Vectors, 16, Article 267. https://doi.org/10.1186/s13071-023-05880-4
• Pfeiffer, D., Robinson, T., Stevenson, M., Stevens, K., Rogers, D., & Clements, A. (2008). Spatial analysis in epidemiology. Oxford University Press.
• Prüss-Ustün, A., Wolf, J., Bartram, J., Clasen, T., Cumming, O., Freeman, M. C., Gordon, B., Hunter, P. R., Medlicott, K., & Johnston, R. (2019). Burden of disease from inadequate water, sanitation and hygiene for selected adverse health outcomes: An updated analysis with a focus on low- and middle-income countries. International Journal of Hygiene and Environmental Health, 222(5), 765–777. https://doi.org/10.1016/j.ijheh.2019.05.004
• Prüss-Ustün, A., Wolf, J., Corvalán, C., Bos, R., & Neira, M. (2016, September 13). Preventing disease through healthy environments: A global assessment of the burden of disease from environmental risks. World Health Organization. https://www.who.int/publications/i/item/9789241565196
• Puspita, T., Suryatma, A., Simarmata, O. S., Veridona, G., Lestary, H., Anwar, A., Pambudi, I., Sulistyo, & Pakasi, T. T. (2021). Spatial variation of tuberculosis risk in Indonesia, 2010–2019. Health Science Journal of Indonesia, 12(2), 104–110. https://hsji.kemkes.go.id/hsji/article/view/1123
• Reiner, R. C., Jr., Le Menach, A., Kunene, S., Ntshalintshali, N., Hsiang, M. S., Perkins, T. A., Greenhouse, B., Tatem, A. J., Cohen, J. M., & Smith, D. L. (2015). Mapping residual transmission for malaria elimination. eLife, 4, Article e09520. https://doi.org/10.7554/eLife.09520
• Reid, H., Vallely, A., Taleo, G., Tatem, A. J., Kelly, G., Riley, I., Harris, I., Henri, I., Iamaher, S., & Clements, A. C. A. (2010). Baseline spatial distribution of malaria prior to an elimination programme in Vanuatu. Malaria Journal, 9, Article 150. https://doi.org/10.1186/1475-2875-9-150
• Roux, A. V. D. (2012). Conceptual approaches to the study of health disparities. Annual Review of Public Health, 33, 41–58. https://doi.org/10.1146/annurev-publhealth-031811-124534
• Rudan, I., Boschi-Pinto, C., Biloglav, Z., Mulholland, K., & Campbell, H. (2008). Epidemiology and etiology of childhood pneumonia. Bulletin of the World Health Organization, 86(5), 408–416. https://doi.org/10.2471/BLT.07.048769
• Santos, M. B., dos Santos, A. D., da Silva, P. P., Barreto, A. S., dos Santos, E. O., França, A. V. C., Barbosa, C. S., & de Araújo, K. C. G. M. (2017). Spatial analysis of viral hepatitis and schistosomiasis coinfection in an endemic area in Northeastern Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 50(3), 383–387. https://doi.org/10.1590/0037-8682-0411-2016
• Shahari, S., Abdullah, M. L., Rohimly, A. A. I., Ashrat, N., Amir, A., Atroosh, W. M. M., Fong, M. Y., & Lau, Y. L. (2024). The prevalence of simian malaria in wild long-tailed macaques throughout Peninsular Malaysia. Scientific Reports, 14, Article 6023. https://doi.org/10.1038/s41598-024-54981-2
• Sunaryo, Ikawati, B., & Wijayanti, T. (2021). Spatial distribution of malaria vector breeding sites in Purworejo District, Central Java Province. Aspirator: Journal of Vector-Borne Diseases Studies, 13(1), 1–8. https://doi.org/10.22435/asp.v13i1.4023
• Tam, P. I., Chirombo, J., Henrion, M., Newberry, L., Mambule, I., Everett, D., Mwansambo, C., Cunliffe, N., French, N., Heyderman, R. S., Bar-Zeev, N., & VACS Consortium. (2022). Clinical pneumonia in the hospitalised child in Malawi in the post-pneumococcal conjugate vaccine era: A prospective hospital-based observational study. BMJ Open, 12, Article e050188. https://doi.org/10.1136/bmjopen-2021-050188
• Vela, M. B., Erondu, A. I., Smith, N. A., Peek, M. E., Woodruff, J. N., & Chin, M. H. (2022). Eliminating explicit and implicit biases in health care: Evidence and research needs. Annual Review of Public Health, 43, 477–501. https://doi.org/10.1146/annurev-publhealth-052620-103528
• Wang, C., Thakuri, B., Roy, A. K., Mondal, N., Qi, Y., & Chakraborty, A. (2023). Changes in the associations between malaria incidence and climatic factors across malaria endemic countries in Africa and the Asia–Pacific region. Journal of Environmental Management, 331, Article 117264. https://doi.org/10.1016/j.jenvman.2023.117264
• Wang, F., Yuan, Z., Qin, S., Qin, F., Zhang, J., Mo, C., Kang, Y., Huang, S., Jiang, J., Liu, A., Liang, H., & Ye, L. (2024). The effects of meteorological factors and air pollutants on the incidence of tuberculosis in people living with HIV/AIDS in subtropical Guangxi, China. BMC Public Health, 24, Article 1333. https://doi.org/10.1186/s12889-024-18475-0
• World Health Organization (WHO). (2025, March 20). Integrated approach to tuberculosis and lung health: Policy brief. https://www.who.int/publications/i/item/9789240107526
• Yamada, A. B. F., de Freitas, P. L., da Silva, R. F., & Souto, F. J. D. (2021). Trends and spatial distribution of hepatitis D in the North of Brazil, 2009–2018: An ecological study. Epidemiologia e Serviços de Saúde, 30(4), Article e2020867. https://doi.org/10.1590/S1679-49742021000400014
• Yamba, E. I., Fink, A. H., Tompkins, A. M., Badu, K., Asare, E. O., & Amekudzi, L. K. (2023). Climate drivers of malaria transmission seasonality and their relative importance in sub-Saharan Africa. GeoHealth, 7, e2022GH000698. https://doi.org/10.1029/2022GH000698
• Yitageasu, G., Feleke, H., Andualem, Z., Demoze, L., Asrat, K., & Gizaw, Z. (2024). Detection of spatial, temporal and spatiotemporal distribution of diarrhea incidence among under-five children in Central Gondar zone, Northwest Ethiopia: A time-series study (2019–2022). BMC Pediatrics, 24, 433. https://doi.org/10.1186/s12887-024-04900-1
• Zacarías-Hernández, J. L., Flores-Aréchiga, A., Tamez-Guerra, R. S., Rivera-Morales, L. G., Castro-Garza, J., Becerril-Montes, P., Vázquez-Cortés, C. G., de la O-Cavazos, M., Vázquez-Guillén, J. M., & Rodríguez-Padilla, C. (2025). Geographical location and genotyping analysis of pulmonary tuberculosis in the state of Nuevo Leon, Mexico. Scientific Reports, 15, Article 7098. https://doi.org/10.1038/s41598-025-90579-y